Microstructure-dependent DC set switching behaviors of Ge-Sb-Te-based phase-change random access memory devices accessed by in situ TEM

Phase-change random access memory (PCRAM) is one of the most promising nonvolatile memory devices. However, inability to secure consistent and reliable switching operations in nanometer-scale programing volumes limits its practical use for highdensity applications. Here, we report in situ transmission electron microscopy investigation of the DC set switching of Ge-Sb-Te (GST)-based vertical PCRAM cells. We demonstrate that the microstructure of GST, particularly the passive component surrounding the dome-shaped active switching volume, plays a critical role in determining the local temperature distribution and is therefore responsible for inconsistent cell-to-cell switching behaviors. As demonstrated by a PCRAM cell with a highly crystallized GST matrix, the excessive Joule heat can cause melting and evaporation of the switching volume, resulting in device failure. The failure occurred via two-step void formation due to accelerated phase separation in the molten GST by the polaritydependent atomic migration of constituent elements. The presented real-time observations contribute to the understanding of inconsistent switching and premature failure of GST-based PCRAM cells and can guide future design of reliable PCRAM.1176Ysciescopu

Toxicity assessment of modified Cry1Ac1 proteins and genetically modified insect-resistant Agb0101 rice

Insect-resistant Agb0101 rice was recently developed by modifying the cry1ac1 gene by changing codon usage changes relative to the native truncated cry1ac1 gene. To assess the toxicity of genetically modified Agb0101 rice, we conducted bioinfomational comparisons of the amino acid sequences that are not similar to known toxic proteins. Sufficient quantities of mCry1Ac1 protein were produced in Escherichia coli for in vitro evaluation and animal study. We compared the amino acid sequences and molecular mass. There have the same amino acid sequences and molecular masses after purifying the modified Cry1Ac1 (mCry1Ac1) protein from highly expressed bacteria and genetically modified rice were identical. We also investigated the acute and 90-days oral toxicities. No adverse effects were observed in mice following acute oral exposure to 2,000 mg/ kg body weight mCry1Ac1 protein of body weight and 90 days oral exposure to Agb0101. These results indicate that mCry1Ac1 proteins and Agb0101 rice demonstrate no adverse effects in these tests when applied via gavage and feed, respectively.Key words: Modified Cry1Ac1, food safety assessment, toxicity, insect- resistant rice Agb0101

Poly(A) RNA and Paip2 act as allosteric regulators of poly(A)-binding protein

When bound to the 30 poly(A) tail of mRNA, poly(A)binding protein (PABP) modulates mRNA translation and stability through its association with various proteins. By visualizing individual PABP molecules in real time, we found that PABP, containing four RNA recognition motifs (RRMs), adopts a conformation on poly(A) binding in which RRM1 is in proximity to RRM4. This conformational change is due to the bending of the region between RRM2 and RRM3. PABP-interacting protein 2 actively disrupts the bent structure of PABP to the extended structure, resulting in the inhibition of PABP-poly(A) binding. These results suggest that the changes in the configuration of PABP induced by interactions with various effector molecules, such as poly(A) and PABP-interacting protein 2, play pivotal roles in its function.X1143sciescopu

Delayed Lubricant Depletion of Slippery Liquid Infused Porous Surfaces Using Precision Nanostructures

Slippery liquid infused porous surfaces (SLIPS) are an important class of repellent materials, comprising micro/nanotextures infused with a lubricating liquid. Unlike superhydrophobic surfaces, SLIPS do not rely on a stable air-liquid interface and thus can better manage low surface tension fluids, are less susceptible to damage under physical stress, and are able to self-heal. However, these collective properties are only efficient as long as the lubricant remains infused, which has proved challenging. We hypothesized that, in comparison to a nanohole and nanopillar morphology, the "hybrid" morphology of a hole within a nanopillar, namely a nanotube, would be able to retain and redistribute lubricant more effectively, owing to capillary forces trapping a reservoir of lubricant within the tube, while lubricant between tubes can facilitate redistribution to depleted areas. By virtue of recent fabrication advances in spacer defined intrinsic multiple patterning (SDIMP), we fabricated an array of silicon nanotubes and equivalent arrays of nanoholes and nanopillars (pitch, 560 nm; height, 2 μm). After infusing the nanostructures (prerendered hydrophobic) with lubricant Krytox 1525, we probed the lubricant stability under dynamic conditions and correlated the degree of the lubricant film discontinuity to changes in the contact angle hysteresis. As a proof of concept, the durability test, which involved consecutive deposition of droplets onto the surface amounting to 0.5 L, revealed 2-fold and 1.5-fold enhancements of lubricant retention in nanotubes in comparison to nanopillars and nanoholes, respectively, showing a clear trajectory for prolonging the lifetime of a slippery surface

On using visibility correlations to probe the HI distribution from the dark ages to the present epoch I: Formalism and the expected signal

Redshifted 21 cm radiation originating from the cosmological distribution of neutral hydrogen (HI) appears as a background radiation in low frequency radio observations. The angular and frequency domain fluctuations in this radiation carry information about cosmological structure formation. We propose that correlations between visibilities measured at different baselines and frequencies in radio-interferometric observations be used to quantify the statistical properties of these fluctuations. This has an inherent advantage over other statistical estimators in that it deals directly with the visibilities which are the primary quantities measured in radio-interferometric observations. Also, the visibility correlation has a very simple relation with power spectrum. We present estimates of the expected signal for nearly the entire post-recombination era, from the dark ages to the present epoch. The epoch of reionization, where the HI has a patchy distribution, has a distinct signature where the signal is determined by the size of the discrete ionized regions. The signal at other epochs, where the HI follows the dark matter, is determined largely by the power spectrum of dark matter fluctuations. The signal is strongest for baselines where the antenna separations are within a few hundred times the wavelength of observation, and an optimal strategy would preferentially sample these baselines. In the frequency domain, for most baselines the visibilities at two different frequencies are uncorrelated beyond \Delta \nu ~ 1 MHz, a signature which in principle would allow the HI signal to be easily distinguished from the continuum sources of contamination.Comment: 12 pages, 9 figures, Accepted to MNRAS; Replaced to match version accepted in MNRA

An Efficient Representation of Euclidean Gravity I

We explore how the topology of spacetime fabric is encoded into the local structure of Riemannian metrics using the gauge theory formulation of Euclidean gravity. In part I, we provide a rigorous mathematical foundation to prove that a general Einstein manifold arises as the sum of SU(2)_L Yang-Mills instantons and SU(2)_R anti-instantons where SU(2)_L and SU(2)_R are normal subgroups of the four-dimensional Lorentz group Spin(4) = SU(2)_L x SU(2)_R. Our proof relies only on the general properties in four dimensions: The Lorentz group Spin(4) is isomorphic to SU(2)_L x SU(2)_R and the six-dimensional vector space of two-forms splits canonically into the sum of three-dimensional vector spaces of self-dual and anti-self-dual two-forms. Consolidating these two, it turns out that the splitting of Spin(4) is deeply correlated with the decomposition of two-forms on four-manifold which occupies a central position in the theory of four-manifolds.Comment: 31 pages, 1 figur

GMRT observation towards detecting the Post-reionization 21-cm signal

We have analyzed 610 MHz GMRT observations towards detecting the redshifted 21-cm signal from z=1.32. The multi-frequency angular power spectrum C_l(Delta nu) is used to characterize the statistical properties of the background radiation across angular scales ~20" to 10', and a frequency bandwidth of 7.5 MHz with resolution 125 kHz. The measured C_l(Delta nu) which ranges from 7 mK^2 to 18 mK^2 is dominated by foregrounds, the expected HI signal C_l^HI(Delta nu) ~10^{-6}- 10^{-7} mK^2 is several orders of magnitude smaller. The foregrounds, believed to originate from continuum sources, is expected to vary smoothly with Delta nu whereas the HI signal decorrelates within ~0.5 MHz and this holds the promise of separating the two. For each l, we use the interval 0.5 < Delta nu < 7.5 MHz to fit a fourth order polynomial which is subtracted from the measured C_l(Delta nu) to remove any smoothly varying component across the entire bandwidth Delta nu < 7.5 MHz. The residual C_l(Delta nu), we find, has an oscillatory pattern with amplitude and period respectively ~0.1 mK^2 and Delta nu = 3 MHz at the smallest l value of 1476, and the amplitude and period decreasing with increasing l. Applying a suitably chosen high pass filter, we are able to remove the residual oscillatory pattern for l=1476 where the residual C_l(Delta nu) is now consistent with zero at the 3-sigma noise level. We conclude that we have successfully removed the foregrounds at l=1476 and the residuals are consistent with noise. We use this to place an upper limit on the HI signal whose amplitude is determined by x_HI b where x_HI and b are the HI neutral fraction and the HI bias respectively. A value of x_HI b greater than 7.95 would have been detected in our observation, and is therefore ruled out at the 3-sigma level. (abridged)Comment: 29 pages, 13 figures, Accepted to MNRA

Ultrafast valley-resolved carrier dynamics in group IV semiconductors

Attosecond transient absorption spectroscopy at the M4,5-edge of Ge following ultrafast photoexcitation reveals valley-resolved hot electron and hole relaxation, carrier recombination and trapping in Ge and Si-Ge alloy in unprecedented clarity and simultaneously

The CMBR fluctuations from HI perturbations prior to reionization

Loeb and Zaldarriaga (2003) have recently proposed that observations of the CMBR brightness temperature fluctuations produced by the HI inhomogeneities prior to reionization hold the promise of probing the primordial power spectrum to a hitherto unprecedented level of accuracy. This requires a precise quantification of the relation between density perturbations and brightness temperature fluctuations. Brightness temperature fluctuations arise from two sources (1.) fluctuations in the spin temperature, and (2.) fluctuations in the HI optical depth, both of which are caused by density perturbations. For the spin temperature, we investigate in detail its evolution in the presence of HI fluctuations. For the optical depth, we find that it is affected by density perturbations both directly and through peculiar velocities which move the absorption features around in frequency. The latter effect, which has not been included in earlier studies, is similar to the redshift space distortion seen in galaxy surveys and this can cause changes of 50% or more in the birghtness temperature fluctuations.Comment: Minor Changes, Submitted to MNRA